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Ultrasearch review two criteria2/16/2023 ![]() Since the beginning of the COVID-19 pandemic in December 2019, more than 418 million cases have been reported worldwide across 223 countries and territories, with more than 5.8 million deaths. Nonetheless, remdesivir remains an important option for physicians in aiming to provide optimal care and relieve pressure on healthcare systems through shifting phases of the pandemic. ConclusionsĮconomic evidence relating to remdesivir should be interpreted with consideration of the broader clinical context, including patients’ characteristics and the timing of its administration. In three out of four included economic evaluations, remdesivir treatment scenarios were cost-effective, ranging from ~ 8 to ~ 23% of the willingness-to-pay threshold for the respective country. Cost estimates for remdesivir ranged widely, from $10 to $780 for a 10-day course. Remdesivir was associated with a 6% to 21.3% decrease in bed occupancy. ![]() ![]() Over time, the prescription rate of remdesivir increased and time from disease onset to remdesivir initiation decreased. ResultsĮight studies reported resource use and five reported costs related to remdesivir. Articles were reviewed for relevance against pre-specified criteria by two independent reviewers and study quality was assessed using published checklists. Searches of MEDLINE, Embase the International Health Technology Assessment (HTA) database, reference lists, congresses and grey literature were performed in May 2021. This systematic literature review (SLR) aimed to summarise economic evaluations, and cost and resource use (CRU) evidence related to remdesivir during the COVID-19 pandemic. As of February 2022, remdesivir is the only US Food and Drug Administration (FDA)-approved treatment for severe COVID-19. The coronavirus disease 2019 (COVID-19) pandemic has been a global health emergency since December 2019, leading to millions of deaths worldwide and placing significant pressures, including economic burden, on individual patients and healthcare systems.
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